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| Seuring, Stefan |
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| Nor Azizi, S. |
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| Pato, Margarida Vaz |
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| Kölker, Katrin |
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| Huber, Oliver |
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| Király, Tamás |
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| Spengler, Thomas Stefan |
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| Al-Ammar, Essam A. |
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| Dargahi, Fatemeh |
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| Mota, Rui |
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| Mazalan, Nurul Aliah Amirah |
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| Macharis, Cathy | Brussels |
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| Arunasari, Yova Tri |
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| Nunez, Alfredo | Delft |
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| Bouhorma, Mohammed |
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| Bonato, Matteo |
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| Fitriani, Ira |
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| Autor Correspondente Coelho, Sílvia. |
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| Pond, Stephen |
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| Okwara, Ukoha Kalu |
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| Toufigh, Vahid |
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| Campisi, Tiziana | Enna |
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| Ermolieva, Tatiana |
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| Sánchez-Cambronero, Santos |
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| Agzamov, Akhror |
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Bellander, Tom
in Cooperation with on an Cooperation-Score of 37%
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Publications (24/24 displayed)
- 2024Long-term exposure to air pollution and chronic kidney disease-associated mortality–Results from the pooled cohort of the European multicentre ELAPSE-studycitations
- 2024Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohortcitations
- 2024Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer: results from the large pooled European cohort of the ELAPSE project.citations
- 2024Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohortcitations
- 2023Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohortcitations
- 2023Long-term air pollution exposure and malignant intracranial tumours of the central nervous systemcitations
- 2023Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts
- 2023Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohortcitations
- 2022Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollutioncitations
- 2022Exposure to surrounding greenness and natural-cause and cause-specific mortality in the ELAPSE pooled cohortcitations
- 2022Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohortcitations
- 2022Long-Term Exposure to Source-Specific Fine Particles and Mortality-A Pooled Analysis of 14 European Cohorts within the ELAPSE Projectcitations
- 2022Long-term exposure to low ambient air pollution concentrations and mortality among 28 million peoplecitations
- 2022Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohortcitations
- 2022Long-term Air Pollution Exposure and Pneumonia-related Mortality in a Large Pooled European Cohortcitations
- 2021Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohortcitations
- 2021Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PM2.5, BC, NO2, and O3: An Analysis of European Cohorts in the ELAPSE Project
- 2021Long-term low-level ambient air pollution exposure and risk of lung cancercitations
- 2021Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality—a Pooled Analysis of Eight European Cohorts within the ELAPSE Projectcitations
- 2021Modeling multi-level survival data in multi-center epidemiological cohort studiescitations
- 2021Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart diseasecitations
- 2020Development of Europe-Wide Models for Particle Elemental Composition Using Supervised Linear Regression and Random Forestcitations
- 2019A comparison of linear regression, regularization, and machine learning algorithms to develop Europe-wide spatial models of fine particles and nitrogen dioxidecitations
- 2018Spatial PM2.5, NO2, O3 and BC models for Western Europe – Evaluation of spatiotemporal stabilitycitations
Places of action
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article
Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort
Abstract
<p>BACKGROUND: An association between long-term exposure to fine particulate matter (PM2.5) and lung cancer has been established in previous studies. PM2.5 is a complex mixture of chemical components from various sources and little is known about whether certain components contribute specifically to the associated lung cancer risk. The present study builds on recent findings from the "Effects of Low-level Air Pollution: A Study in Europe" (ELAPSE) collaboration and addresses the potential association between specific elemental components of PM2.5 and lung cancer incidence.</p><p>METHODS: We pooled seven cohorts from across Europe and assigned exposure estimates for eight components of PM2.5 representing non-tail pipe emissions (copper (Cu), iron (Fe), and zinc (Zn)), long-range transport (sulfur (S)), oil burning/industry emissions (nickel (Ni), vanadium (V)), crustal material (silicon (Si)), and biomass burning (potassium (K)) to cohort participants' baseline residential address based on 100 m by 100 m grids from newly developed hybrid models combining air pollution monitoring, land use data, satellite observations, and dispersion model estimates. We applied stratified Cox proportional hazards models, adjusting for potential confounders (age, sex, calendar year, marital status, smoking, body mass index, employment status, and neighborhood-level socio-economic status).</p><p>RESULTS: The pooled study population comprised 306,550 individuals with 3,916 incident lung cancer events during 5,541,672 person-years of follow-up. We observed a positive association between exposure to all eight components and lung cancer incidence, with adjusted HRs of 1.10 (95% CI 1.05, 1.16) per 50 ng/m3 PM2.5 K, 1.09 (95% CI 1.02, 1.15) per 1 ng/m3 PM2.5 Ni, 1.22 (95% CI 1.11, 1.35) per 200 ng/m3 PM2.5 S, and 1.07 (95% CI 1.02, 1.12) per 200 ng/m3 PM2.5 V. Effect estimates were largely unaffected by adjustment for nitrogen dioxide (NO2). After adjustment for PM2.5 mass, effect estimates of K, Ni, S, and V were slightly attenuated, whereas effect estimates of Cu, Si, Fe, and Zn became null or negative.</p><p>CONCLUSIONS: Our results point towards an increased risk of lung cancer in connection with sources of combustion particles from oil and biomass burning and secondary inorganic aerosols rather than non-exhaust traffic emissions. Specific limit values or guidelines targeting these specific PM2.5 components may prove helpful in future lung cancer prevention strategies.</p>
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