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| Seuring, Stefan |
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| Nor Azizi, S. |
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| Pato, Margarida Vaz |
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| Kölker, Katrin |
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| Huber, Oliver |
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| Király, Tamás |
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| Spengler, Thomas Stefan |
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| Al-Ammar, Essam A. |
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| Dargahi, Fatemeh |
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| Mota, Rui |
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| Mazalan, Nurul Aliah Amirah |
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| Macharis, Cathy | Brussels |
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| Arunasari, Yova Tri |
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| Nunez, Alfredo | Delft |
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| Bouhorma, Mohammed |
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| Bonato, Matteo |
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| Fitriani, Ira |
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| Autor Correspondente Coelho, Sílvia. |
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| Pond, Stephen |
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| Okwara, Ukoha Kalu |
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| Toufigh, Vahid |
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| Campisi, Tiziana | Enna |
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| Ermolieva, Tatiana |
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| Sánchez-Cambronero, Santos |
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| Agzamov, Akhror |
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Bellander, Tom
in Cooperation with on an Cooperation-Score of 37%
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Publications (24/24 displayed)
- 2024Long-term exposure to air pollution and chronic kidney disease-associated mortality–Results from the pooled cohort of the European multicentre ELAPSE-studycitations
- 2024Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohortcitations
- 2024Long-term exposure to several constituents and sources of PM2.5 is associated with incidence of upper aerodigestive tract cancers but not gastric cancer: results from the large pooled European cohort of the ELAPSE project.citations
- 2024Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohortcitations
- 2023Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohortcitations
- 2023Long-term air pollution exposure and malignant intracranial tumours of the central nervous systemcitations
- 2023Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts
- 2023Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohortcitations
- 2022Long term exposure to air pollution and kidney parenchyma cancer – Effects of low-level air pollutioncitations
- 2022Exposure to surrounding greenness and natural-cause and cause-specific mortality in the ELAPSE pooled cohortcitations
- 2022Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohortcitations
- 2022Long-Term Exposure to Source-Specific Fine Particles and Mortality-A Pooled Analysis of 14 European Cohorts within the ELAPSE Projectcitations
- 2022Long-term exposure to low ambient air pollution concentrations and mortality among 28 million peoplecitations
- 2022Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohortcitations
- 2022Long-term Air Pollution Exposure and Pneumonia-related Mortality in a Large Pooled European Cohortcitations
- 2021Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohortcitations
- 2021Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PM2.5, BC, NO2, and O3: An Analysis of European Cohorts in the ELAPSE Project
- 2021Long-term low-level ambient air pollution exposure and risk of lung cancercitations
- 2021Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality—a Pooled Analysis of Eight European Cohorts within the ELAPSE Projectcitations
- 2021Modeling multi-level survival data in multi-center epidemiological cohort studiescitations
- 2021Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart diseasecitations
- 2020Development of Europe-Wide Models for Particle Elemental Composition Using Supervised Linear Regression and Random Forestcitations
- 2019A comparison of linear regression, regularization, and machine learning algorithms to develop Europe-wide spatial models of fine particles and nitrogen dioxidecitations
- 2018Spatial PM2.5, NO2, O3 and BC models for Western Europe – Evaluation of spatiotemporal stabilitycitations
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article
Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort
Abstract
<p>Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson's Disease (PD) remains limited. Objective: We examined the association between long-term exposure to ambient air pollution and PD mortality in seven European cohorts. Methods: Within the project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM<sub>2.5</sub>), nitrogen dioxide (NO<sub>2</sub>), black carbon (BC), and ozone (O<sub>3</sub>), as well as 8 PM<sub>2.5</sub> components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders. Results: Of 271,720 cohort participants, 381 died from PD during 19.7 years of follow-up. In single-pollutant analyses, we observed positive associations between PD mortality and PM<sub>2.5</sub> (hazard ratio per 5 µg/m<sup>3</sup>: 1.25; 95% confidence interval: 1.01–1.55), NO<sub>2</sub> (1.13; 0.95–1.34 per 10 µg/m<sup>3</sup>), and BC (1.12; 0.94–1.34 per 0.5 × 10<sup>-5</sup>m<sup>-1</sup>), and a negative association with O<sub>3</sub> (0.74; 0.58–0.94 per 10 µg/m<sup>3</sup>). Associations of PM<sub>2.5</sub>, NO<sub>2</sub>, and BC with PD mortality were linear without apparent lower thresholds. In two-pollutant models, associations with PM<sub>2.5</sub> remained robust when adjusted for NO<sub>2</sub> (1.24; 0.95–1.62) or BC (1.28; 0.96–1.71), whereas associations with NO<sub>2</sub> or BC attenuated to null. O<sub>3</sub> associations remained negative, but no longer statistically significant in models with PM<sub>2.5</sub>. We detected suggestive positive associations with the potassium component of PM<sub>2.5</sub>. Conclusion: Long-term exposure to PM<sub>2.5</sub>, at levels well below current EU air pollution limit values, may contribute to PD mortality.</p>
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